The effect of copper deficiency on the induction of tryptophan pyrrolase in chick liver by hydrocortisone.
نویسندگان
چکیده
The induction of tryptophan pyrrolase in chick liver by hydrocortisone was studied in copper- and magnesium-deficient chicks. Magnesium deficiency did not influence the induction of the enzyme, whereas copper deficiency significantly decreased it. These results suggest that tryptophan pyrrolase of chick liver, like that in Pseudomonas, is a copper-containing enzyme.
منابع مشابه
The functional significance of changes in activity of the enzymes, tryptophan pyrrolase and tyrosine transaminase, after induction in intact rats and in the isolated, perfused rat liver.
The possible functional significance of induction of the hepatic enzymes, tryptophan pyrrolase and tyrosine transaminase, has been studied in intact normal and adrenalectomized adult male rats and in the isolated perfused rat liver. In intact, normal rats, several-fold increases in tryptophan pyrrolase activity induced by treatment with hydrocortisone or tryptophan, or both, were associated wit...
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The induction of tryptophan pyrrolase by hydroeortisone has been studied in rats following 70% hepatectomy. An alteration in the rate of induction was observed in both sham-operated and 70% hepatectomized rats early in the postoperative period. Normal maximal values were eventually reached, however. Later in the postoperative period, induction patterns were similar to those observed in unoperat...
متن کاملThe Journal of Biological Chemwcry
The possible functional significance of induction of the hepatic enzymes, tryptophan pyrrolase and tyrosine transaminase, has been studied in intact normal and adrenalectomized adult male rats and in the isolated perfused rat liver. In intact, normal rats, several-fold increases in tryptophan pyrrolase activity induced by treatment with hydrocortisone or tryptophan, or both, were associated wit...
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An activation of tryptophan pyrrolase in vitro distinct from the previously known conversion of inactive apotryptophan pyrrolase to active holotryptophan pyrrolase by hematin or by boiled particulate fractions of liver is described. This stimulation occurs by the addition of small amounts of mitochondria or microsomes to cell sap in the presence of excess methemoglobin. The particulate activato...
متن کاملThe Roles of Synthesis and Degradation in the Control of Rat Liver Tryptophan Pyrrolase.
It is now well established that in animal tissues a large number of enzyme activities can be increased by the administration of hormones (l-3), by specific substrates (1, 4), or by alterations in the nutritional state of the animal (58). In certain of these cases an increased content of newly synthesized enzyme protein has been shown to account for the increases in enzyme activity, as opposed t...
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 103 1 شماره
صفحات -
تاریخ انتشار 1967